Ghazala Butt, Ammad A. Farooqi*, Aima Adylova, Rukset Attar, Seher Yilmaz, Konysbayeva K. Konysbayevna, Uteuliyev Y. Sabitaliyevich, Maria L. Gasparri and Baojun Xu* Pages 1868 - 1875 ( 8 )
Treatment options for effective treatment of cancer with minimum off-target effects and maximum clinical outcomes have remained overarching goals in the clinical oncology. Vitamin C has remained in the shadows of controversy since the past few decades; burgeoning evidence has started to shed light on wide-ranging anticancer effects exerted by Vitamin C to induce apoptosis in drug-resistant cancer cells, inhibit uncontrolled proliferation of the cancer cells and metastatic spread. Landmark achievements in molecular oncology have ushered in a new era, and researchers have focused on the identification of oncogenic pathways regulated by Vitamin C in different cancers. However, there are visible knowledge gaps in our understanding related to the ability of Vitamin C to modulate a myriad of transduction cascades. There are scattered pieces of scientific evidence about promising potential of Vitamin C to regulate JAK-STAT, TGF/SMAD, TRAIL and microRNAs in different cancers. However, published data is insufficient and needs to be investigated comprehensively to enable basic and clinical researchers to reap full benefits and promote result-oriented transition of Vitamin C into various phases of clinical trials. In this review, we will emphasize on available evidence related to the regulation of oncogenic cell signaling pathways by Vitamin C in different cancers. We will also highlight the conceptual gaps, which need detailed and cutting-edge research.
Vitamin C, Anticancer, Signaling pathways, Protein network, Clinical trials, Clinical oncology.
Department of Botany, Government College University, Lahore, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty, Department of Obstetrics and Gynecology, Yeditepe University, Istanbul, Department of Anatomy, Yozgat Bozok University, Faculty of Medicine, Yozgat, Ministry of Health of the Republic of Kazakhstan, Zhibek zholy 5, Almaty, Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty, Department of Obstetrics and Gynecology, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Universita’ della Svizzera Italiana, Lugano, Food Science and Technology Program, BNU-HKBU United International College, Zhuhai 519087