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Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity

[ Vol. 20 , Issue. 21 ]

Author(s):

Xinjia Yan, Jing Wen, Lin Zhou, Lei Fan, Xiaobo Wang* and Zhi Xu*   Pages 1916 - 1937 ( 22 )

Abstract:


Cancer, which has been cursed for human beings for long time is considered as one of the leading causes of morbidity and mortality across the world. In spite of different types of treatments available, chemotherapy is still deemed as a favored treatment for the cancer. Unfortunately, many currently accessible anticancer agents have developed multidrug resistance along with fatal adverse effects. Therefore, intensive efforts have been made to seek for new active drugs with improved anticancer efficacy and reduced adverse effects. In recent years, the emergence of heterocyclic ring-containing anticancer agents has gained a great deal of attention among medicinal chemists. 1,3- oxazole is a versatile heterocyclic compound, and its derivatives possess broad-spectrum pharmacological properties, including anticancer activity against both drug-susceptible, drug-resistant and even multidrug-resistant cancer cell lines through multiple mechanisms. Thus, the 1,3-oxazole moiety is a useful template for the development of novel anticancer agents. This review will provide a comprehensive overview of the recent advances on 1,3-oxazole derivatives with potential therapeutic applications as anticancer agents, focus on the chemical structures, anticancer activity, and mechanisms of action.

Keywords:

1, 3-oxazole, Anticancer, Drug-resistant, Mechanisms of action, Drug-susceptible, Heterocycles.

Affiliation:

Department of Pharmacy, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian, College of Pharmacy, Harbin University of Commerce, Harbin, Department of Pharmacy, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian, Department of Pharmacy, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian, Department of Pharmacy, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian, College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang 550025

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