Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application

Author(s):

Mukesh C. Joshi* and Timothy J. Egan   Pages 617 - 697 ( 81 )

Abstract:

The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC’s with the help of fragmented amino acid, thus lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.

Keywords:

Chloroquine, P. falciparum, Antiplasmodial activity, β-HI activity, Cytotoxicity, Quinoline.

Affiliation:

Department of Chemistry, Motilal Nehru College, Benito Juarez Marg, South Campus, University of Delhi, New Delhi- 110021, Department of Chemistry, University of Cape Town, Rondebosch 7701

Graphical Abstract:

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