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Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry

[ Vol. 19 , Issue. 17 ]

Author(s):

Anatoly Sorokin*, Vsevolod Shurkhay, Stanislav Pekov, Evgeny Zhvansky, Daniil Ivanov, Eugene E. Kulikov, Igor Popov, Alexander Potapov and Eugene Nikolaev   Pages 1521 - 1534 ( 14 )

Abstract:


Cells metabolism alteration is the new hallmark of cancer, as well as an important method for carcinogenesis investigation. It is well known that the malignant cells switch to aerobic glycolysis pathway occurring also in healthy proliferating cells. Recently, it was shown that in malignant cells de novo synthesis of the intracellular fatty acid replaces dietary fatty acids which change the lipid composition of cancer cells noticeably. These alterations in energy metabolism and structural lipid production explain the high proliferation rate of malignant tissues. However, metabolic reprogramming affects not only lipid metabolism but many of the metabolic pathways in the cell. 2-hydroxyglutarate was considered as cancer cell biomarker and its presence is associated with oxidative stress influencing the mitochondria functions. Among the variety of metabolite detection methods, mass spectrometry stands out as the most effective method for simultaneous identification and quantification of the metabolites. As the metabolic reprogramming is tightly connected with epigenetics and signaling modifications, the evaluation of metabolite alterations in cells is a promising approach to investigate the carcinogenesis which is necessary for improving current diagnostic capabilities and therapeutic capabilities. In this paper, we overview recent studies on metabolic alteration and oncometabolites, especially concerning brain cancer and mass spectrometry approaches which are now in use for the investigation of the metabolic pathway.

Keywords:

Metabolic reprogramming, Mass spectrometry, Brain cancer, Oncometabolites, Metabolism, Lipids.

Affiliation:

Laboratory of Ion and Molecular Physics, Moscow Institute of Physics and Technology, Dolgoprudnyi, Federal State Autonomous Institution, N.N. Burdenko National Scientific and Practical Center for Neurosurgery of the Ministry of Healthcare of the Russian Feaderation, Moscow, Laboratory of Ion and Molecular Physics, Moscow Institute of Physics and Technology, Dolgoprudnyi, Laboratory of Ion and Molecular Physics, Moscow Institute of Physics and Technology, Dolgoprudnyi, Laboratory of Ion and Molecular Physics, Moscow Institute of Physics and Technology, Dolgoprudnyi, Department of molecular and biological physics, Moscow Institute of Physics and Technology, Dolgoprudny, Laboratory of Ion and Molecular Physics, Moscow Institute of Physics and Technology, Dolgoprudnyi, Federal State Autonomous Institution, N.N. Burdenko National Scientific and Practical Center for Neurosurgery of the Ministry of Healthcare of the Russian Feaderation, Moscow, Skolkovo Institute of Science and Technology, Skolkovo



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