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Role of Natural Product in Modulation of Drug Transporters and New Delhi Metallo-β Lactamases

Author(s):

Brinda Chandar* and Debdutta Bhattacharya*   Pages 1 - 11 ( 11 )

Abstract:


The rapid growth in the drug resistance has bought the treatment options to treat antimicrobial resistance to halt. Bacteria evolve to accumulate many genes that code resistance for a single drug within a single cell. Drug transporters are the major factors for the pharmacokinetics of drugs and alternations of drug transport is one of the causes for interactions.Conversely, the production of enzymes also inactivates most antibiotics. Discovery of newer classes of antibiotics and drugs from natural products are the need of the hour. Alternatives medicines also play an integral part across the globe that requires validation for treatment strategies. It is essential to explore the chemical diversity for specific activity and determine the mechanism of action of these drugs. This review describes the interaction of drugs against antimicrobial resistance with a special focus on natural product-derived efflux pump and carbapenemase inhibitors.

Keywords:

Multi-drug resistance, β- lactamases, NDM-1, efflux pump, Herbal drug

Affiliation:

Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, ICMR-Regional Medical Research Centre (Dept. of Health Research, Govt. of India), Chandrasekharpur, Bhubaneswar



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