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Article Details


How cancer cells resist chemotherapy: Design and Development of Drugs Targeting

Author(s):

Vadim V. Tarasov Tarasov, Vladimir N. Chubarev, Ghulam Md Ashraf, Samira A. Dostdar, Alexander V. Sokolov, Tatiana I. Melnikova, Susanna S. Sologova, Ekaterina M. Grigorevskich, Alfiya Makhmutovа, Alexander S. Kinzirsky, Sergey G. Klochkov and Gjumrakch Aliev*  

Abstract:


Nowadays, it is well known that tumor is not a simple set of cells, but a highly organized structure, which can adapt to the changing conditions of adverse microenvironment, including exposure to chemotherapy. In this review, we have discussed the feasibility of prediction of development general and specific resistance mechanisms to chemotherapy. It is shown that not all theoretical knowledge about factors of drug resistance, including alteration in DNA-repair machinery, drug reflux, autophagy, apoptosis evasion, immune system evasion, the influence of tumor microenvironment etc. underlying general and specific resistance mechanisms could be used for forecasting drug resistance in clinical practice. Here, we present a concept for a rational- designed study that could provide reliable information whether the marker is clinically significant or not.

Keywords:

Cancer, drug resistance, chemotherapy, biomarkers, protein-protein interaction.

Affiliation:

Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991



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