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Influence of Amino Acid Mutations and Small Molecules for Targeted Inhibition of Proteins Involved in Cancer

Author(s):

Vishnupriya Kanakaveti, P. Anoosha, R. Sakthivel, S. K. Rayala and M. Michael Gromiha*  

Abstract:


Protein-protein interactions (PPIs) are of crucial importance in regulating the biological processes of cells both in normal and diseased conditions. Recently, significant progress has been made in targeting PPIs using small molecules and achieved promising results. In this review, we focus on the advancements in computational research for targeted inhibition of proteins involved in cancer on two aspects: (i) understand the key roles of amino acid mutations in epidermal growth factor receptor (EGFR) as well as mutation-specific inhibitors and (ii) design of small molecule inhibitors for Bcl-2 to disrupt PPIs. First part deals with preferred driver mutations prone to cancer, identification of driver mutations and development of mutation-specific inhibitors for EGFR. In the second part of the review, we discuss on various computational methods for designing inhibitors for Bcl-2 supported with experimental observations. Further, recent trends and various approaches to identify potential lead compounds on these target proteins along with further perspectives will be outlined.

Keywords:

EGFR, Bcl-2, protein-protein interactions, drug targets, mutation

Affiliation:

Protein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Protein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Protein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Molecular Oncology Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai , Protein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai



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