Ritu Kataria and Anurag Khatkar* Pages 116 - 122 ( 7 )
Several phenolic compounds bind to proteins (such as enzymes) and interfere in their catalytic mechanism. Interaction studies of natural polyphenol; Resveratrol with various targets like with tubulin, protein kinase C alpha (PKCα), phosphodiesterase-4D, human oral cancer cell line proteins, DNA sequences having AATT/TTAA segments, protein kinase C alpha, lysine-specific demethylase 1 have been reviewed in this article. Simulation studies indicate that resveratrol and its analogs/ derivatives show good interaction with the target receptor through its hydroxyl groups by forming hydrogen bonds and hydrophobic interactions with amino acid residues at the binding site. Binding geometry and stability of complex formed by resveratrol show that it is a good inhibitor for many pathogenic targets. Further studies in this direction is, however, the need of the hour to develop many more ligands based on resveratrol skeleton which can further serve in the treatment of ailments.
Resveratrol, Molecular Docking, Anticancer, Urease inhibition, Protein kinase C alpha, AATT/TTAA.
International Institute of Pharmaceutical Sciences, Sonepat, Haryana, Laboratory of Preservation Technology and Enzyme Inhibition Studies, Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana