Yu Bai, Daid Ahmad, Ting Wang*, Guihua Cui and Wenliang Li* Pages 1 - 9 ( 9 )
The causes and progression of cancer are controlled by epigenetic processes. The mechanisms involved in epigenetic regulation of cancer development, gene expression, and signaling pathways have been studied. Histone deacetylases (HDACs) have a major impact on chromatin remodeling and epigenetics, making their inhibitors a very interesting area of cancer research. This review comprehensively summarizes the literature regarding HDAC inhibitors (HDACis) as an anticancer treatment published in the past few years. In addition, we explain the mechanisms of their therapeutic effects on cancer. An analysis of the beneficial characteristics and drawbacks of HDACis also is presented, which will assist preclinical and clinical researchers in the design of future experiments to improve the therapeutic efficacy of these drugs and circumvent the challenges in the path of successful epigenetic therapy. Future therapeutic strategies may include a combination of HDACis and chemotherapy or other inhibitors to target multiple oncogenic signaling pathways.
Histone deacetylase (HDAC) inhibitors, cancer, mechanisms, histone deacetylases, epigenetic therapy, signaling pathways.
School of Pharmacy, Jilin Medical University, Jilin, Department of Nanotechnology Engineering, University of Waterloo, Waterloo, Department of the Gastrointestinal Surgery, The first Hospital of Jilin University, Changchun, Jilin, School of Pharmacy, Jilin Medical University, Jilin, School of Pharmacy, Jilin Medical University, Jilin