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Biological Activities of Artemisinin Derivatives Beyond Malaria

Author(s):

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen  

Abstract:


Artemisinin is isolated from Artemisia annua L with peroxide-containing sesquiterpene lactone structure. Because of its unique structural characteristics and promising anticancer, antivirus activities, it has recently received increasing attention. The aim of this review is to summarize recent discoveries of artemisinin's novel derivatives with new pharmaceutical effects beyond malaria with a focus on its antitumor and antivirus activity, as well as potential results of combination therapy with other clinical drugs.

Keywords:

Artemisinin, Artemisinin derivatives, Antiviral activity, Anticancer activity, Dimer, Trimer.

Affiliation:

CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 201418, College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 201418, CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203



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