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Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Antioxidant and Anti-hyperglycemic Activity

Author(s):

Kanika Varshney, Amit K. Gupta, Ravi Sonkar, Salil Varshney, Akanksha Mishra, Geetika Bhatia, Anil Gaikwad, Arvind Kumar Srivastava, Mridula Saxena, Sudha Jain* and Anil K. Saxena*   Pages 1 - 10 ( 10 )

Abstract:


A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Among these 12 compounds the three compounds 6c, 7b and 7d showed good anti-oxidant activity and the compound 6c attenuataed LDL oxidation by 32%. The compounds 6c and 7d also showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for anti-adipogenic and anti-hyperglycemic activity, where 6c was found most active compound with 44% reduction in lipid accumulation and 20.5% and 24.3% reduction in blood glucose at 5h and 24h respectively, as compared to standard drug metformin.

Keywords:

Hydrazone derivatives; Anti-oxidant; Anti-dyslipidemic; Atherosclerosis.

Affiliation:

Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow, 226031, Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, Biochemistry Division, Central Drug Research Institute, Lucknow, 226031, Pharmacology Division, Central Drug Research Institute, Lucknow, 226031, Biochemistry Division, Central Drug Research Institute, Lucknow, 226031, Biochemistry Division, Central Drug Research Institute, Lucknow, 226031, Pharmacology Division, Central Drug Research Institute, Lucknow, 226031, Biochemistry Division, Central Drug Research Institute, Lucknow, 226031, Pharmacology Division, Central Drug Research Institute, Lucknow, 226031, Department of Chemistry, Amity University, Lucknow, Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow, 226031



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