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Dengue Fever: A Worldwide Threat An Overview of the Infection Process, Environmental Factors for a Global Outbreak, Diagnostic Platforms and Vaccine Developments

[ Vol. 18 , Issue. 18 ]


Samira Hosseini*, Jacqueline Oliva-Ramírez, Patricia Vázquez-Villegas, Aida Rodriguez-Garcia, Rodrigo B. Muñoz-Soto, Nasrin Aghamohammadi* and Sergio O. Martinez-Chapa   Pages 1531 - 1549 ( 19 )


Current review article focuses on dengue, which is one of the most fatal infectious illnesses and is considered to be a worldwide threat. The paper covers essential topics including an overview on neglected tropical diseases with specific emphasis on Dengue fever, mosquito's cycle of life and mechanism of infection, adaptive response, and different stages in dengue immunopathogenesis. The current work is also dedicated to the thorough study of dengue outbreak across the globe with a narrowed study to tropical and subtropical regions. Moreover, this review article demonstrates the correlation between climate factors and dengue incidence. Furthermore, we present an overview of the detection strategies of dengue including the latest developments in commercial and non-commercial platforms. Several attempts in developing an effective vaccine to protect individuals from dengue infection and the stage of clinical trials are gathered in the present work as well. Future directions including bio-control are also discussed in this review article. In an overall view, effective management of Dengue is a multidisciplinary task that requires international involvement from different backgrounds and expertise to address this global concern. This review article briefly portrays some of these connecting areas across the disciplines while many other perspectives remain uncovered.


Dengue fever, Dengue immunopathogenesis, Dengue outbreak, Effect of climate factors on Dengue, Detection platforms for Dengue, Bio-control of Dengue.


Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey, N.L, Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Ave. Lago de Guadalupe Km 3.5, Cd Lopez Mateos, Atizapan, Estado de Mexico, N.L, Tecnologico de Monterrey, Writing Lab, TecLabs, Vicerrectoria de Investigacion y Transferencia de Tecnologia, Monterrey 64849, NL, Universidad Autonoma de Nuevo Leon, Facultad de Ciencias Biologicas, Instituto de Biotecnologia. Ave. Pedro de Alba S/N, Ciudad Universitaria, CP. 66455, San Nicolas de los Garza, Nuevo Leon, Tecnologico de Monterrey, Campus Ciudad de Mexico, Escuela de Ingenieria y Ciencias, Calle del Puente 222, Mexico City, Centre for Occupational and Environmental Health, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey, N.L

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