Luiz Felipe Domingues Passero*, Lucas Antal Cruz, Gabriela Santos-Gomes, Eliana Rodrigues, Márcia Dalastra Laurenti and João Henrique Ghilardi Lago Pages 1275 - 1286 ( 12 )
Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus. There are at least 16 pathogenic species for humans that are able to cause different clinical forms, such as cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment is performed with few drug options that, in most cases, are considered outdated. In addition, patients under classical treatment show serious side effects during drug administration, moreover parasites are able to become resistant to medicines. Thus, it is believed and well accepted that is urgent and necessary to develop new therapeutic options to overpass these concerns about conventional therapy of leishmaniasis. The present review will focus on the efficacy, side effects and action mechanism of classic drugs used in the treatment of leishmaniasis, as well as the importance of traditional knowledge for directing a rational search toward the discovery and characterization of new and effective molecules (in vivo assays) from plants to be used against leishmaniasis.
Leishmaniasis, Conventional drugs, Ethnopharmacology, New drugs, Molecules, Amphotericin.
Institute of Biosciences, Sao Paulo State University (UNESP), Sao Vicente. Praca Infante Dom Henrique, s/n, 11330- 900 Sao Vicente, SP, Institute of Biosciences, Sao Paulo State University (UNESP), Sao Vicente. Praca Infante Dom Henrique, s/n, 11330- 900 Sao Vicente, SP, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisboa, Center for Ethnobotanical and Ethnopharmacoly Studies (CEE), Institute of Environmental Sciences, Chemical and Pharmaceutical, Universidade Federal de Sao Paulo (UNIFESP) 04021-001, Department of Pathology, Laboratory of Pathology of Infectious Diseases (LIM50), Medical School of Sao Paulo University, Av. Dr. Arnaldo, 455. Cerqueira Cesar, São Paulo, 01246- 903, SP, Center of Natural Sciences and Humanities, Federal University of ABC, Santo Andre, Sao Paulo, 09210-180