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Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy

[ Vol. 18 , Issue. 14 ]

Author(s):

Carolina Anazco*, Armando Rojas, Ileana Gonzalez, Maite A. Castro, Paz Robert and Felipe Oyarzun-Ampuero*   Pages 1242 - 1251 ( 10 )

Abstract:


Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance of that tissue. Lysyl oxidases, also known as LOX enzymes, are the major collagen cross-linking enzymes that play a pivotal role in homeostasis. This minireview summarizes evidence that describes an amino oxidase-like activity, which could be attributed to polyphenols, or where polyphenols could be required. We also discuss some available collagen formulations and the scientific evidence that describes the impact on dermal extracellular matrix. In addition, information about encapsulation strategies to carry polyphenols, and some examples are also provided.

Keywords:

Polyphenols, Flavonoids, Lysyl Oxidase, Basement membrane, Collagen, Skin, Aging, Extracellular matrix, Dermis, Encapsulation.

Affiliation:

Departamento de Ciencias Pre- Clínicas, Laboratorio de Investigaciones Biomedicas, Facultad de Medicina, Universidad Catolica del Maule, Av. San Miguel 3605, Talca 3480112, Departamento de Ciencias Pre- Clínicas, Laboratorio de Investigaciones Biomedicas, Facultad de Medicina, Universidad Catolica del Maule, Av. San Miguel 3605, Talca 3480112, Departamento de Ciencias Pre- Clínicas, Laboratorio de Investigaciones Biomedicas, Facultad de Medicina, Universidad Catolica del Maule, Av. San Miguel 3605, Talca 3480112, Instituto de Bioquimica y Microbiologia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Departamento de Ciencias de los Alimentos y Tecnologia Quimica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Departamento de Ciencias y Tecnología Farmaceuticas, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494

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