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Role of Noncoding RNA in Pulmonary Arterial Hypertension and Potential Drug Therapeutic Target

[ Vol. 18 , Issue. 12 ]

Author(s):

Chi-yuan Zhang, Mo liu, Jia-ming Wan, Ming-qi Gao, Yue Zhang, Muscab Soyan, Huai-Liang Wang and Yang Bai*   Pages 975 - 986 ( 12 )

Abstract:


Pulmonary arterial hypertension (PAH) is a devastating disease without effective drugs available for its treatment. An in-depth exploration of the pathogenesis of PAH, as well as inquiry into potential therapeutic targets, remains an urgent issue. Non-coding RNAs (ncRNAs) have arisen as key players in malignant tumors, cardiovascular diseases and more recently in PAH progression and development. Network pharmacology is a new discipline based on system biology, which can predict potential therapeutic targets in diseases regulated by multiple genes. In this review, we discuss the current knowledge of ncRNAs and network pharmacology regulated genes involved in PAH, as well as the search for potential drug targets for PAH.

Keywords:

Pulmonary arterial hypertension, Noncoding RNA, Drugs, miRNA, LncRNA, Network.

Affiliation:

Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, Department of Clinical Pharmacology, College of Pharmacy, China Medical University, Shenyang, China Medical University, Shenyang, 110122, Department of Clinical Pharmacology, College of Pharmacy, China Medical University, Shenyang, China Medical University, Shenyang, 110122, China Medical University, Shenyang, 110122, Department of Clinical Pharmacology, College of Pharmacy, China Medical University, Shenyang, Department of Clinical Pharmacology, College of Pharmacy, China Medical University, Shenyang

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