Alvaro Gonzalez-Dominguez, Alfonso Maria Lechuga-Sancho and Raul Gonzalez-Dominguez* Pages 896 - 900 ( 5 )
Observational experimental designs are usually employed in metabolomics to elucidate pathological mechanisms underlying disease development and to discover candidate biomarkers for diagnosis. However, intervention trials can also be a suitable starting point before performing a validation study in lager epidemiological cohorts, with a great potential in personalized medicine to investigate how different patients respond to similar stimuli. In the present work, we provide a review of the literature on the application of metabolomics to investigate metabolic alterations associated with diabetes, the diabetes predisposing state of insulin resistance and the oral glucose tolerance test as a case study to demonstrate the complementarity of observational and interventional study designs.
Metabolomics, diabetes, oral glucose tolerance test, insulin resistance, study design, observational study, interventional study.
Department of Pediatrics, Hospital Universitario Puerta del Mar. Cadiz, 11009, Department of Pediatrics, Hospital Universitario Puerta del Mar. Cadiz, 11009, Institute of Research and Innovation in Biomedical Sciences of the Province of Cadiz (INiBICA), Cadiz