Submit Manuscript  

Article Details


Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

[ Vol. 18 , Issue. 10 ]

Author(s):

Salma E. Ahmed, Nahid Awad, Vinod Paul, Hesham G. Moussa and Ghaleb A. Husseini*   Pages 857 - 880 ( 24 )

Abstract:


Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Keywords:

Chemotherapy, multi-drug resistance, anthracyclines, doxorubicin, nano-carriers, ultrasound.

Affiliation:

Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah, Department of Electrical Engineering, American University of Sharjah, Sharjah, Department of Chemical Engineering, American University of Sharjah, Sharjah

Graphical Abstract:



Read Full-Text article