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The Development of New Small-Molecule Inhibitors Targeting Bacterial Metallo-β-lactamases

[ Vol. 18 , Issue. 10 ]

Author(s):

Ping Wang, Jing Cheng, Cong-Cong Liu, Kai Tang, Feng Xu, Zhiqiang Yu, Bin Yu* and Junbiao Chang*   Pages 834 - 843 ( 10 )

Abstract:


Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistant pathogens, which now represent a major threat to human health. As there is not to date yet a clinically available MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors.

Keywords:

Metallo-β-lactamases, thiol derivatives, dicarboxylic acid derivatives, cyclic Boronates, triazoles, natural products, peptide inhibitors.

Affiliation:

Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou 510033, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001

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