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Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases

[ Vol. 18 , Issue. 5 ]

Author(s):

Carolina L. Bellera, Maria L. Sbaraglini and Alan Talevi*   Pages 369 - 381 ( 13 )

Abstract:


Neglected diseases comprise a number of infectious diseases historically endemic to low- and middle-income countries, though recently they have spread to high-income countries due to human migrations. In the past, pharmaceutical companies have shown hesitant to invest in these health conditions, due to the limited return on investment. As a result, the role of the academic sector and not-for-profit organizations in the discovery of new drugs for neglected diseases has been particularly relevant.

Here, we review recent applications of modern drug discovery technologies in the field of neglected diseases, including high-throughput screening, in silico screening and computer-aided drug design. The suitability and perspectives of each approach are discussed depending on the context, along with the technology and translational gaps influencing them.

Keywords:

Drug repurposing, Drug repositioning, In silico screening, Virtual screening, High-throughput screening, Computer- aided drug discovery, Neglected diseases, Infectious diseases.

Affiliation:

Department of Biological Sciences, Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata (UNLP), La Plata, Department of Biological Sciences, Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata (UNLP), La Plata, Department of Biological Sciences, Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata (UNLP), La Plata

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