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Alternative Methods to Animal Studies for the Evaluation of Topical/ Transdermal Drug Delivery Systems

[ Vol. 18 , Issue. 4 ]

Author(s):

Maria Teresa Junqueira Garcia, Fabia Leal Lopes de Vasconcellos, Chloe Patricia Raffier, Michael Stephen Roberts, Jeffrey Ernest Grice, Heather Ann Elizabeth Benson and Vania Rodrigues Leite-Silva*   Pages 287 - 299 ( 13 )

Abstract:


It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/permeation studies.

Keywords:

Skin penetration, Drug delivery systems, Alternative methods, In vivo, Ex vivo, In silico, Skin permeation.

Affiliation:

Instituto de Ciencias Ambientais Quimicas e Farmaceuticas, Universidade Federal de Sao Paulo, Diadema SP, Instituto de Ciencias Ambientais Quimicas e Farmaceuticas, Universidade Federal de Sao Paulo, Diadema SP, Therapeutics Research Centre, the University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Therapeutics Research Centre, the University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Therapeutics Research Centre, the University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Instituto de Ciencias Ambientais Quimicas e Farmaceuticas, Universidade Federal de Sao Paulo, Diadema SP

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