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Aurora Kinase Inhibitors in Head and Neck Cancer

[ Vol. 18 , Issue. 3 ]

Author(s):

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*   Pages 199 - 213 ( 15 )

Abstract:


Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

Keywords:

Aurora kinases, Mitosis, Head and neck cancer, Aurora kinase inhibitor, Tumor, Biological function.

Affiliation:

Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8504, Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8504, Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8504

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