Zhen-Feng Chen*, Chris Orvig and Hong Liang* Pages 3131 - 3145 ( 15 )
There has been a growing interest in the rational design of multi-targeted drugs with the aim of enhancing overall efficacy and/or improving safety. The development of multi-targeted drugs might yield new avenues in the treatment of cancers that involve multiple pathogenic factors. In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticancer agents are also proposed.
Multi-target, metal complexes, cytotoxicity, anticancer agents, nickel complexes, pathogenic factors.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, Department of Chemistry, Faculty of Science, The University of British Columbia, 2036 Main Mall Vancouver, V6T 1Z1 BC, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004