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Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications

[ Vol. 17 , Issue. 20 ]

Author(s):

Yong Siang Ong, Liqian Gao, Karunakaran A. Kalesh, Zhiqiang Yu*, Jigang Wang, Chengcheng Liu, Yiwen Li, Hongyan Sun* and Su Seong Lee*   Pages 2302 - 2318 ( 17 )

Abstract:


Cyclic peptides, owing to their good stability, high resistance to exo- and to some extent endo-peptidases, enhanced binding affinity and selectivity towards target biomolecules, are actively investigated as biochemical tools and therapeutic agents. In this review, we discuss various commonly utilized synthetic strategies for cyclic peptides and peptoids (peptidomimetics), their important screening methods to identify the bioactive cyclic peptides and peptoids such as combinatorial beadbased peptide library, phage display, mRNA display etc. and recent advances in their applications as bioactive compounds. Lastly, we also make a summary and provide an outlook of the research area.

Keywords:

Cyclic peptide, Cyclization, Bead-based library, Phage display, mRNA display, Computational.

Affiliation:

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London - SW7 2AZ, School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, Guangdong 510515, College of Life Sciences, The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, Bioprocessing Technology Institute, 20 Biopolis Way, #06-01 Centros, Singapore 138668, College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669

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