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Self-assembled Nucleic Acid Nanostructures for Cancer Theranostic Medicines

[ Vol. 17 , Issue. 16 ]

Author(s):

Jinglin Fu*, Gabriele Stankeviciute, Sung Won Oh, John Collins, Yinghui Zhong and Ting Zhang   Pages 1815 - 1828 ( 14 )

Abstract:


Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.

Keywords:

Cancer theranostics, DNA nanotechnology, Spherical nucleic acids, DNA nanorobot, Smart drug delivery.

Affiliation:

Center for Computational and Integrative Biology, Department of Chemistry, Rutgers University-Camden, 315 Penn Street, Science Building, Camden, NJ 08102, Department of Chemistry, Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, Department of Chemistry, School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, PA, Department of Chemistry

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