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Antimicrobial AApeptides

[ Vol. 17 , Issue. 11 ]

Author(s):

Peng Sang, Yan Shi, Peng Teng, Annie Cao, Hai Xu, Qi Li and Jianfeng Cai   Pages 1266 - 1279 ( 14 )

Abstract:


Antibiotic resistance is one of the biggest public concerns in the 21st century. Host-defense peptides (HDPs) can potentially mitigate the problem through bacterial membrane disruption; however, they suffer from moderate activity and low stability. We recently developed a new class of peptidomimetics termed “AApeptides”. This class of peptidomimetics can mimic the mechanism of action of HDPs, and effectively arrest the growth of multidrug resistant Gram-positive and Gram-negative bacteria. As they are built on unnatural backbone, they are resistant to proteolytic degradation. In this review, we summarize the development of this class of antimicrobial peptidomimetics, and discuss the future perspective on how they can move forward on combating antibiotic resistance.

Keywords:

Antibiotic resistance, Host-defense peptides (HDPs), AApeptides, Peptidomimetics, Antimicrobial activity.

Affiliation:

Department of Chemistry, University of South Florida, Tampa, FL, 33260,, Department of Chemistry, University of South Florida, Tampa, FL, 33260,, Department of Chemistry, University of South Florida, Tampa, FL, 33260,, Department of Chemistry, University of South Florida, Tampa, FL, 33260,, College of Chemistry and Chemical Engineering, Central South University, Changsha, HN 410083,, Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203,, Department of Chemistry, University of South Florida, Tampa

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