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Oxazole: A Promising Building Block for the Development of Potent Antitumor Agents

[ Vol. 16 , Issue. 30 ]

Author(s):

Hua Zhou, Jiang-Qun Cheng, Zhi-Sen Wang, Fei-Hu Chen and Xin-Hua Liu   Pages 3582 - 3589 ( 8 )

Abstract:


Oxazole derivatives are found to have a variety of biological activities. A large number of studies have revealed their outstanding anticancer activities. Here we review four different types of oxazole derivatives with anticancer potential reported over the last ten years. We focus our discussion on their activity, selectivity in different cancer cell lines, mechanisms of action, and their structural evolution.

Keywords:

Activity, Annulated oxazole, Anticancer inhibitors, Oxazole, Oxazolidinone, Macrocyclic.

Affiliation:

School of Pharmacy, Anhui Medical University, Hefei 230032, China.

Graphical Abstract:



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