Submit Manuscript  

Article Details

Multivariate Analysis of Magnetic Resonance Imaging Signals of the Human Brain

[ Vol. 16 , Issue. 24 ]


Yoichi Miyawaki   Pages 2685 - 2693 ( 9 )


Magnetic resonance imaging (MRI) of the human brain plays an important role in the field of medical imaging as well as basic neuroscience. It measures proton spin relaxation, the time constant of which depends on tissue type, and allows us to visualize anatomical structures in the brain. It can also measure functional signals that depend on the local ratio of oxyhemoglobin to deoxyhemoglobin in the blood, which is believed to reflect the degree of neural activity in the corresponding area. MRI thus provides anatomical and functional information about the human brain with high spatial resolution. Conventionally, MRI signals are measured and analyzed for each individual voxel. However, these signals are essentially multivariate because they are measured from multiple voxels simultaneously, and the pattern of activity might carry more useful information than each individual voxel does. This paper reviews recent trends in multivariate analysis of MRI signals in the human brain, and discusses applications of this technique in the fields of medical imaging and neuroscience.


Magnetic resonance imaging, Medical imaging, Neuroscience, Machine learning, Pattern classification, Diagnosis, perception, Vision.


Center for Frontier Science and Engineering, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan.

Graphical Abstract:

Read Full-Text article