Submit Manuscript  

Article Details


Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

[ Vol. 16 , Issue. 27 ]

Author(s):

Elina Buitrago, Renaud Hardré, Romain Haudecoeur, Hélène Jamet, Catherine Belle, Ahcène Boumendjel, Luigi Bubacco and Marius Réglier   Pages 3033 - 3047 ( 15 )

Abstract:


Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.

Keywords:

Melanoma, Tyrosinase, TRP-1, TRP-2, Tyrosinase effectors.

Affiliation:

ISM2 UMR CNRS 7313, Centre Scientifique de Saint Jérôme, Aix Marseille Université, 13397, Marseille cedex 20, France.

Graphical Abstract:



Read Full-Text article