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Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option

[ Vol. 16 , Issue. 19 ]

Author(s):

María Laura Sbaraglini, María Cristina Vanrell, Carolina Leticia Bellera, Gustavo Benaim, Carolina Carrillo, Alan Talevi and Patricia Silvia Romano   Pages 2201 - 2222 ( 22 )

Abstract:


Neglected tropical diseases represent a major sanitary problem and a huge economic burden to endemic countries, and are currently expanding to non-endemic countries owing to migration currents. Though long abandoned in the past, recent research on novel therapeutics has already started to show results. Drug repositioning is one of the prominent, more successful strategies to approach the development of new treatments for these diseases. Here we present an overview on the limitations of the current available medications to treat African trypanosomiasis, Chagas disease and Leishmaniasis, along with a review on drug candidates presently undergoing clinical trials and drug candidates identified through drug repositioning initiatives.

Keywords:

African trypanosomiasis, Chagas disease, Clinical trials, Drug discovery, Drug repositioning, Drug repurposing, Leishmaniasis, Neglected tropical diseases.

Affiliation:

Instituto de Ciencias y Tecnología César Milstein, Saladillo 2468, Ciudad Autónoma de Buenos Aires (1440), Argentina., Faculty of Exact Sciences, National University of La Plata, 47 y 115, La Plata (1900), Argentina., Faculty of Medical Sciences, National University of Cuyo, Avenida Libertador 80, Mendoza (5500), Argentina.

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