Radhika Narayanaswamy, Tao Wang and Vladimir P. Torchilin Pages 253 - 270 ( 18 )
Peptides are being successfully used in various fields including therapy and drug delivery. With advancement in nanotechnology and targeted delivery carrier systems, suitable modification of peptides has enabled achievement of many desirable goals over-riding some of the major disadvantages associated with the delivery of peptides in vivo. Conjugation or physical encapsulation of peptides to various nanocarriers, such as liposomes, micelles and solid-lipid nanoparticles, has improved their in vivo performance multi-fold. The amenability of peptides to modification in chemistry and functionalization with suitable nanocarriers are very relevant aspects in their use and have led to the use of ‘smart’ nanoparticles with suitable linker chemistries that favor peptide targeting or release at the desired sites, minimizing off-target effects. This review focuses on how nanotechnology has been used to improve the number of peptide applications. The paper also focuses on the chemistry behind peptide conjugation to nanocarriers, the commonly employed linker chemistries and the several improvements that have already been achieved in the areas of peptide use with the help of nanotechnology.
Applications, Carriers, Chemistry, Linkers, Nanotechnology, Peptides, Targeted delivery.
Northeastern University, Center for Pharmaceutical Biotechnology and Nanomedicine, 140 The Fenway Building, 360 Huntington Avenue, Boston, MA 02115, USA.