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Inhibitors of Leucine-Rich Repeat Kinase 2 (LRRK2): Progress and Promise for the Treatment of Parkinson’s Disease

[ Vol. 15 , Issue. 10 ]

Author(s):

Paul J. Gilligan   Pages 927 - 938 ( 12 )

Abstract:


Mutations in the gene for leucine-rich repeat kinase 2 (LRRK2) have been linked to several familial and sporadic late-onset cases of Parkinson’s disease. The cumulative data for the effects of mutant forms of this enzyme on neuronal degradation and the pathophysiology of Parkinson’s disease create a compelling case for drug discovery based on inhibition of the mutant forms of LRRK2. This review focuses on structure-activity relationships for inhibitors of LRRK2 and the data supporting a potential role of these agents in treating Parkinson’s disease.

Keywords:

Kinase inhibitors, Leucine-rich repeat kinase 2 (LRRK2), Parkinson’s disease.

Affiliation:

The Pennsylvania Drug Discovery Institute, 3805 Old Easton Road, Doylestown, PA 18902, USA.

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