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Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection

[ Vol. 15 , Issue. 5 ]

Author(s):

Upinder Kaur, Priyanjalee Banerjee, Aritri Bir, Maitrayee Sinha, Atanu Biswas and Sasanka Chakrabarti   Pages 446 - 457 ( 12 )

Abstract:


Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-κBsignaling cascade has been discussed in the end.

Keywords:

Alzheimer’s disease, Amyloid beta, Cytokines, NF-κB, Oxidative stress, Redox signaling.

Affiliation:

Department of Biochemistry, Institute of Post Graduate Medical and Educational Research, 244, AJC Bose Road, Kolkata-700020, India.

Graphical Abstract:



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