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Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

[ Vol. 15 , Issue. 3 ]


Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone and Thibaud Coradin   Pages 223 - 244 ( 22 )


The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.


Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.


Chimie de la Matiere Condensee, College de France, 11 place Marcelin Berthelot, 75005 Paris, France.

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