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Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

[ Vol. 15 , Issue. 3 ]

Author(s):

Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone and Thibaud Coradin   Pages 223 - 244 ( 22 )

Abstract:


The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.

Keywords:

Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.

Affiliation:

Chimie de la Matiere Condensee, College de France, 11 place Marcelin Berthelot, 75005 Paris, France.

Graphical Abstract:



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