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Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

[ Vol. 14 , Issue. 23 ]

Author(s):

Andres R. Alcantara, Vittorio Pace, Pilar Hoyos, Manuel Sandoval, Wolfgang Holzer and Maria J. Hernaiz   Pages 2694 - 2711 ( 18 )

Abstract:


Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.

Keywords:

Carbohydrates, Glycomimetic, Biocatalysis, Antidiabetic drugs, Anticancer drugs.

Affiliation:

Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Campus de Moncloa, 30100 Madrid, Spain.

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