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Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs

[ Vol. 14 , Issue. 21 ]


Edelmiro Moman   Pages 2398 - 2407 ( 10 )


The development of non-microbial methods for the selective functionalization of non-activated C-H bonds has constituted a challenge, with important economical and environmental implications, for chemists for over a century. The present review provides a comprehensive and current compendium that illustrates the power of C-H functionalization and, namely, of remote functionalization strategies, to expeditiously access vitamin D analogs with intricate structures.


Analogs, calcitriol, Free radical, Non-activated carbons, Remote functionalization, Synthesis, Vitamin D.


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