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Multicomponent Reactions in Antimitotic Drug Discovery

[ Vol. 14 , Issue. 20 ]

Author(s):

Angel Cores, Carlos Carbajales and Alberto Coelho   Pages 2209 - 2230 ( 22 )

Abstract:


As enabling technology, the development and application of multicomponent reactions (MCRs) are now an integral part of the work of any major medical research unit. Targeted MCR approaches focused on specific antimitotic pathways afford new solutions for the medicinal chemistry of the XXI century. In this review, the contribution of these procedures to the discovery of antimitotic drugs that are currently in clinical trials or already in the market is discussed.

Keywords:

Antimitotic, Biginelli, Aurora kinases, KSP, Multicomponent reactions, Ugi.

Affiliation:

Center for Research in Biological Chemistry and Molecular Materials. University of Santiago de Compostela. Spain.

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