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Synthesis of Alkaloids: Recent Advances in the Synthesis of Phenanthroindolizidine Alkaloids

[ Vol. 14 , Issue. 2 ]

Author(s):

Antonio C. B. Burtoloso, Ariane F. Bertonha and Isac G. Rosset   Pages 191 - 199 ( 9 )

Abstract:


Phenanthroindolizidine alkaloids are a well-known class of compounds due to their interesting biological activities, especially anticancer ones. Represented by more than 60 substances, they are mainly isolated from plants of the Moraceae and Asclepiadaceae families. In the last 30 years, a great effort has been made aiming the synthesis of these compounds and analogues to be applied in medicinal chemistry.

Keywords:

Alkaloids, antofine, anticancer, anti-inflammatory, antifungal, antibacterial, biaryl coupling, indolizidines, phenanthroindolizidines, total synthesis, typlophorine, tylocrebrine.

Affiliation:

Instituto de Química de São Carlos, Universidade de São Paulo, CEP 13560-970, São Carlos, SP, Brazil



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