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Prion Chemical Biology: On the Road to Therapeutics?

[ Vol. 13 , Issue. 19 ]

Author(s):

Beining Chen, Mark Thompson, Jennifer Louth and Kai Guo   Pages 2441 - 2464 ( 24 )

Abstract:


Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.

Keywords:

Quinacrine, antiprion, prion protein, drug discovery, indole, prion diseases, pyridine dicarbonitrile, thiazole.

Affiliation:

Dainton Building, Department of Chemistry, University of Sheffield, Brookhill, Sheffield S3 7HF, UK.



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