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Cytochrome P450 2C8 and Drug Metabolism

[ Vol. 13 , Issue. 18 ]

Author(s):

Xiaoping Lv, Fangfang Zhong and Xiangshi Tan   Pages 2241 - 2253 ( 13 )

Abstract:


CYP 2C8, which carries out the oxidative metabolism of at least 5% of clinical drugs, has attracted increasing attention in recent years. New drugs (substances), inducers and inhibitors of CYP 2C8 have been developed and the drug metabolism has been investigated to understand the clinical role of CYP2C8. The cases of CYP2C8 genetic polymorphisms linked to diseases have increased and have been investigated. Herein, important progress in these areas has been reviewed with an emphasis on drug metabolism. Polymorphisms, diseases related to CYP2C8, some important drugs (substances) and inhibitors are reviewed and discussed.

Keywords:

CYP2C8, drug metabolism, disease, polymorphism, inhibitor.

Affiliation:

Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.



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