Submit Manuscript  

Article Details


Targeting TRPs in Neurodegenerative Disorders

[ Vol. 13 , Issue. 3 ]

Author(s):

Yoshinori Takada, Tomohiro Numata and Yasuo Mori   Pages 322 - 334 ( 13 )

Abstract:


Neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis present a significant medical challenge in the modern world. Recent evidence indicates that perturbation of neuronal Ca2+ homeostasis is involved in the pathogenesis of these neurodegenerative disorders. Transient receptor potential (TRP) channels are non-selective cation channels that are expressed in various cell types and tissues, and play an important role in regulating Ca2+ signaling in both non-neuronal and neuronal cells. TRP channels are related to the onset or progression of several diseases, and defects in the genes encoding TRP channels (so-called “TRP channelopathies”) underlie certain neurodegenerative disorders due to their abnormal Ca2+ signaling properties. In this article, we review recent findings regarding the relationship between TRPs and neurodegenerative disorders, and discuss the therapeutic potential of targeting TRP channels pharmacologically.

Keywords:

TRP channels, neurodegenerative disorders, oxidative stress, Ca2+ homeostasis, neuronal cell death, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, epilepsy, ataxia, bipolar disorders, ischemia, stroke, muscle atrophy, channelopathy

Affiliation:

Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.



Read Full-Text article