Barbara Colsoul, Bernd Nilius and Rudi Vennekens Pages 258 - 269 ( 12 )
Transient Receptor Potential (TRP) proteins constitute a family of cation channels with very diverse permeation and gating properties. Likewise they have a very diverse role in mammalian physiology ranging from sensory nerve endings, the cardiac muscle to immune cells. Increasing evidence has implicated TRP channels in the pathology of diabetes, both on the level of insulin release from the pancreatic ß cells and in secondary conditions such as diabetic neuropathy, nephropathy and vasculopathy. In this review we summarize these recent findings, which all together indicate that TRP channels are interesting drug targets for the treatment of patients suffering from diabetes.
Ion channels, diabetes, pancreatic beta cells, insulin, transient receptor potential channels
KU Leuven, Department of Molecular and Cellular Medicine, Laboratory of Ion Channel Research, Campus Gasthuisberg, Herestraat 49, bus 802, B-3000 Leuven, Belgium.