E.L. Schaeffer, W.F. Gattaz and G.P. Eckert Pages 2314 - 2323 ( 10 )
Physiological enzymatic cleavage of membrane phospholipids by phospholipase A2 (PLA2) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA2 (iPLA2) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA2 activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.
schizophrenia, neuroimaging, membrane, phospholipase A2, dopamine
Department of Pharmacology, Goethe-University of Frankfurt, Campus Riedberg, Biocenter, Max-von- Laue Straße 9, 60438 Frankfurt, Germany